Reads to Discovery

Text Mining & NLP analysis of SARS-CoV-2

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): A 50-200 nm virion with a genome size of approximately 30000 nucleotides paused the normal and routine activities of the world by being the causative agent of Coronavirus Disease 2019 (COVID-19). Several questions came flooding when I started to know more about this novel coronavirus. The researcher in … Continue reading “Text Mining & NLP analysis of SARS-CoV-2”

Light switch of plants-HY5

Childhood memories of summer vacation involved watering the plants and taking care of the parent’s garden. It was filled with fun and intrigue as a new shoot with small leaves would sprout from a potato bud, or, out of nowhere a ”Touch me not” plant would grow, and when touched its leaves would shrink. Plants … Continue reading “Light switch of plants-HY5”

Demystifying the odd base conundrum

The picture above has a lot of beads and their colors are primarily shades of blue or pink. But clearly, there is one orange bead that stands out making a difference. In the same way, our DNA is a stitch and stretch of 4 primary chemical beads (bases)- Adenine (A), Thymine (T), Guanine (G), and … Continue reading “Demystifying the odd base conundrum”

The silent biomarkers of stem cells- Small RNA

I was watching this movie, where the protagonists were a race of human clones made from “stem cells” and they try to defend their lives from the native human race. You might have already heard of dolly the sheep, the first cloned animal out of an adult stem cell. Also, the infamous CRISPR babies whose … Continue reading “The silent biomarkers of stem cells- Small RNA”

Strand NGS-Annotation toolbox for organisms

Our planet accommodates a variety of life with their genes: from civilized humans to the colonized bacteria, from infamous mosquito to the cutest puppies, and from golden rice to the greenest algae. Studying these species helps us in understanding the genetics of the species and population diversity and also other biomedical and bio technical applications. … Continue reading “Strand NGS-Annotation toolbox for organisms”

What’s new in Strand NGS 3.4

Data quality is of utmost importance for accurate and valid downstream NGS analysis. Sequence artifacts contribute to erroneous interpretations in analysis. Focusing on this, we have introduced two quality checks to find Overrepresented Sequences and Adapter Content. Trim these sequence artifacts in further steps for accurate downstream analysis Strand NGS 3.4 now supports Agilent UMI … Continue reading “What’s new in Strand NGS 3.4”

Webinar on Diagnosis of Rare Diseases using NGS Based Multi-gene Testing- Case studies 18 Apr

A disease is considered to be ‘rare’ when it affects one in about 2000 individuals in the population. This, individually are although rare, collectively, the incidence could be very high causing a significant socio-economic burden. Arriving at a confirmatory diagnosis is a major challenge in these inherited disorders, which can significantly impact treatment and disease … Continue reading “Webinar on Diagnosis of Rare Diseases using NGS Based Multi-gene Testing- Case studies 18 Apr”

Ultra-sensitive variant calling and transcript quantification using Unique Molecular Identifiers

Background Next Generation Sequencing (NGS) technologies have remarkably revolutionized the medical and genomics research. The incremental cost reductions and size of the throughput at molecular resolution helped penetration and acceptance of the NGS methodologies into worldwide labs and clinics. The third generation wave of NGS technologies are knocking the doors to provide impetus to the … Continue reading “Ultra-sensitive variant calling and transcript quantification using Unique Molecular Identifiers”

Webinar on Unravelling complex mutational events in clinical cases using the power of NGS data analysis on 31 Jan

Live webinar on Unravelling complex mutational events in clinical cases using the power of Next generation sequencing data analysis by Dr Satish Sankaran on 31 Jan 2018 at 9am CET and 8am PST Speaker: Dr. Satish Sankaran, Vice President- Clinical Operations and Laboratory Director- Clinical Lab, Strand Life Sciences Pvt Ltd Abstract: Next Generation sequencing has come a … Continue reading “Webinar on Unravelling complex mutational events in clinical cases using the power of NGS data analysis on 31 Jan”

Webinar on Unique Molecular Identifier (UMI)-powered Ultra-sensitive Variant Calling using Strand NGS on 13 Dec at 2:30 PM and 9:30 PM IST by Dr.Pandurang Kolekar

Unique Molecular Identifiers (UMIs) are short random nucleotide sequences that are increasingly being used in high-throughput sequencing experiments. In this webinar, we will highlight the UMI-friendly features of Strand NGS v3.1 including support for handling well known and customised UMI libraries, QC metrics, consensus alignment, UMI-based family size filters for read list, genome browser enabled … Continue reading “Webinar on Unique Molecular Identifier (UMI)-powered Ultra-sensitive Variant Calling using Strand NGS on 13 Dec at 2:30 PM and 9:30 PM IST by Dr.Pandurang Kolekar”